博士、副教授、硕士生导师，安徽省首批高校“双带头人”教师党支部书记工作室负责人、安徽省高校中青年教师培养行动项目学科（专业）带头人培育对象，87978797威尼斯老品牌党政办公室副主任，87978797威尼斯老品牌卫生毒理学系党支部书记、副主任。学术兼职：安徽省环境诱变剂学会理事兼秘书、安徽省预防医学会卫生毒理专业委员会委员兼秘书。主要研究方向：发育源性疾病的环境病因与机制研究。主持国家自然科学基金面上项目、青年科学基金、安徽省自然科学基金面上项目、安徽省教育厅高校自然科学研究重点项目、安徽省高等学校省级优秀青年人才基金项目和87978797威尼斯老品牌校级科学研究基金课题各1项，参与省部级以上课题多项；以第一作者（含共同第一作者）发表SCI论文15篇。曾获安徽省优秀硕士学位论文、安徽省科学技术奖二等奖、中华预防医学科技奖三等奖、华夏医学科技奖三等奖各1项、中华医学科技奖三等奖3项、校优秀教师、校优秀共产党员、校优秀班主任和校优秀校友工作者。

代表性论文

[1]Fan Zhao #, Lun Zhang #, Mingchao Qu, Lu Ye, Jiayi Zhang, Yun Yu, Qianqian Huang, Cheng Zhang*, Jianqing Wang*. Obeticholic acid alleviates intrauterine growth restriction induced by di-ethyl-hexyl phthalate in pregnant female mice by improving bile acid disorder. Environ Sci Pollut Res Int. 2023; 30(51): 110956-110969. 

[2]Bingdong Song#, Cheng Zhang#, Weirong Hu,  Chunyu Guo, Zhengmei Xia , Wanxia Hu, Mingqiang Qin, Weiying Jiang, Jinwei Lv, Dexiang Xu, Shichen Zhang*, Jun Fang*, Nano-designed carbon monoxide donor SMA/CORM2 exhibits protective effect against acetaminophen induced liver injury through macrophage reprograming and promoting liver regeneration, J Control Release, 2021; 331: 350-363.

[3]Cheng Zhang, Yu Gan, Jin-Wei Lv, Ming-Qiang Qin, Wei-Rong Hu, Zhi-Bing Liu, Li Ma, Bing-Dong Song, Jian Li, Wei-Ying Jiang, Jian-Qing Wang, Hua Wang, De-Xiang Xu*, The protective effect of obeticholic acid on lipopolysaccharide-induced disorder of maternal bile acid metabolism in pregnant mice, Int Immunopharmacol, 2020; 83: 106442.

[4]Qian-Qian Chen#, Cheng Zhang#, Ming-Qiang Qin, Jian Li, Hua Wang, De-Xiang Xu*, Jian-Qing Wang*, Inositol-requiring enzyme 1 alpha endoribonuclease specific inhibitor stf-083010 alleviates carbon tetrachloride induced liver injury and liver fibrosis in mice, Front Pharmacol, 2018; 9: 1344.

[5]Da-Gang Zhang#, Cheng Zhang#, Jun-Xian Wang, Bi-Wei Wang, Hua Wang, Zhi-Hui Zhang, Yuan-Hua Chen, Yan Lu, Li Tao, Jian-Qing Wang, Xi Chen*, De-Xiang Xu*, Obeticholic acid protects against carbon tetrachloride-induced acute liver injury and inflammation, Toxicol Appl Pharmacol, 2017; 314: 39-47.

[6]Jun-Xian Wang#, Cheng Zhang#, Lin Fu, Da-Gang Zhang, Bi-Wei Wang, Zhi-Hui Zhang, Yuan-Hua Chen, Yan Lu, Xi Chen*, De-Xiang Xu*, Protective effect of rosiglitazone against acetaminophen-induced acute liver injury is associated with down-regulation of hepatic NADPH oxidases, Toxicol Lett, 2017; 265: 38-46.

[7]Jia-Hui Huang#, Cheng Zhang#, Da-Gang Zhang, Lu Li, Xi Chen*, De-Xiang Xu*, Rifampicin-Induced Hepatic Lipid Accumulation: Association with Up-Regulation of Peroxisome Proliferator-Activated Receptor γ in Mouse Liver, PLoS One; 2016, 11(11): e0165787.

[8]Ye-Fa Zhang#, Wei He#, Cheng Zhang#, Xiao-Jing Liu, Yan Lu, Hua Wang, Zhi-Hui Zhang, Xi Chen*, De-Xiang Xu*, Role of receptor interacting protein (RIP)1 on apoptosis-inducing factor-mediated necroptosis during acetaminophen-evoked acute liver failure in mice, Toxicol Lett, 2014; 225(3): 445-453.

[9]Jian-Qing Wang#, Xi Chen#, Cheng Zhang#, Li Tao, Zhi-Hui Zhang, Xiao-Qian Liu, Yuan-Bao Xu, Hua Wang, Jun Li*, De-Xiang Xu*, Phenylbutyric acid protects against carbon tetrachloride-induced hepatic fibrogenesis in mice, Toxicol Appl Pharmacol, 2013; 266(2):307-316.

[10]Cheng Zhang#, Xi Chen#, Ren-Min Zhu#, Ying Zhang, Tao Yu, Hua Wang, Hui Zhao, Mei Zhao, Yan-Li Ji, Yuan-Hua Chen, Xiu-Hong Meng, Wei Wei*, De-Xiang Xu*, Endoplasmic reticulum stress is involved in hepatic SREBP-1c activation and lipid accumulation in fructose-fed mice, Toxicol Lett; 2012, 212(3): 229-240.

[11]Xi Chen#, Cheng Zhang#, Mei Zhao, Chang-E Shi#, Ren-Min Zhu, Hua Wang, Hui Zhao, Wei Wei, Jia-Bin Li, De-Xiang Xu*, Melatonin alleviates lipopolysaccharide-induced hepatic SREBP-1c activation and lipid accumulation in mice, J Pineal Res, 2011; 51(4): 416-425.

[12]Xi Chen#, Cheng Zhang#, Hua Wang, Juan Xu, Zi-Hao Duan, Ying Zhang, Tao Yu, Wei Wei, De-Xiang Xu*, Jian-Ming Xu*, Altered integrity and decreased expression of hepatocyte tight junctions in rifampicin-induced cholestasis in mice, Toxicol Appl Pharmacol, 2009; 240 (1): 26-36.

[13]Xiang-Yun Li#, Cheng Zhang#, Su-Fang Wang, Yan-Li Ji, Hua Wang, Lei Zhao, De-Xiang Xu*, Maternally-administered lipopolysaccharide (LPS) upregulates the expression of heme oxygenase-1 in fetal liver: the role of reactive oxygen species, Toxicol Lett, 2008; 176 (3): 169-177.

[14]Xiang-Yun Li#, Cheng Zhang#, HuaWang, Yan-Li Ji, Su-FangWang, Lei Zhao, Xi Chen, De-Xiang Xu*, Tumor necrosis factor alpha partially contributes to lipopolysaccharide-induced downregulation of CYP3A in fetal liver: its repression by a low dose LPS pretreatment, Toxicol Lett, 2008; 179 (2): 71-77.

[15]Cheng Zhang, Xiang-Yun Li, Lei Zhao, Hua Wang, De-Xiang Xu*, Lipopolysaccharide (LPS) up-regulates the expression of haem oxygenase-1 in mouse placenta, Placenta, 2007; 28 (8-9): 951-957.